In his first Six Nations start since 2017, Rhys Webb is back for Wales at scrum-half against Italy on Saturday in Rome.
The 34-year-old steps in for Tomos Williams, who last started a Test three years prior, while Rio Dyer replaces Louis Rees-Zammit on the wings.
Moreover, Dafydd Jenkins, Jac Morgan, Liam Williams, and prop Wyn Jones are added by Wales coach Warren Gatland.
Lock Leigh Halfpenny, Christ Tshiunza, and Alun Wyn Jones are out, and Gareth Thomas is benched.
While Dan Biggar is unable to play due to a back injury, Wales, who are winless, continue to start Joe Hawkins at center and Owen Williams at fly-half.
longtime Ospreys lock Jones and his 22-year-old teammate Rhys Davies are both absent from the squad.